Faculty
Permanent URI for this communityhttps://hdl.handle.net/11209/8744
The institutional repository for scholarship by the faculty of Bennington College
Browse
Browsing Faculty by Subject "Cell Biology"
Now showing 1 - 1 of 1
- Results Per Page
- Sort Options
Item Open Access Quality Control of Protein Folding in the Cytosol(Wilvey, 2012-05) McClellan, Amie J.In order to function properly, newly synthesised proteins must rapidly and efficiently attain their native conformations. If they fail to do so, the cell may be adversely affected due to loss of function or toxic gain of function effects of misfolded polypeptides. Effective quality control mechanisms to recognise and eliminate misfolded proteins are thus critical for cell viability.The primary means by which misfolded proteins are selectively removed from the cell is via the ubiquitin–proteasome system. Although much is known about regulated proteolysis, how any given protein,which could potentially misfold, is recognised and targeted for proteasome-mediated degradation has been challenging to decipher. Recent progress,much of it in yeast, has identified specific E3 ligases involved in this process,clarified or added to our knowledge of the roles of molecular chaperones,and identified multiple cellular locations where degradation, or failing that, aggregation, occurs.